Assay Detail
Functional
CHEMBL2160398
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Cytoprotective activity against glucotoxicity in Sprague-Dawley rat DRG neurons assessed as cell viability by calcein-AM assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | DRG neuron |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of novologues as C-terminal Hsp90 inhibitors with cytoprotective activity against sensory neuron glucotoxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.08 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2159227 | CEMDOMESPIB | 2.0 | 1 | 7.89 |
| CHEMBL2159239 | — | — | 1 | 7.74 |
| CHEMBL2159231 | — | — | 1 | 6.73 |
| CHEMBL460005 | — | — | 1 | 6.62 |
| CHEMBL2159233 | — | — | 1 | 6.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2159227 | CEMDOMESPIB | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL2159239 | — | EC50 | = | 18.4 | nM | 7.74 |
| CHEMBL2159231 | — | EC50 | = | 187.7 | nM | 6.73 |
| CHEMBL460005 | — | EC50 | = | 240.2 | nM | 6.62 |
| CHEMBL2159233 | — | EC50 | = | 384.0 | nM | 6.42 |