Assay Detail

CHEMBL2160684

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Functional

Cytotoxicity against human MCF7 cells

ChEMBL ↗

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Target

MCF7 (CHEMBL387) ↗

Open DB target context

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MCF7 (CHEMBL387) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target MCF7

CHEMBL387

Anchored from Assay target.

Protein identity MCF7

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	MCF7
Confidence	1 — Organism
Curated By	Autocuration

Target

MCF7 (CHEMBL387) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Synthesis and in vitro antitumour screening of 2-(β-D-xylofuranosyl)thiazole-4-carboxamide and two novel tiazofurin analogues with substituted tetrahydrofurodioxol moiety as a sugar mimic.

Popsavin M, Spaić S, Svirčev M, Kojić V, Bogdanović G, Popsavin V.
Bioorg Med Chem Lett (2012) 22 : 6700 -6704
PubMed 23010263 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Activity	1	-	-
IC50	1	6.58	6.58

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL108358	TIAZOFURIN	2.0	1	6.58
CHEMBL2158240	—	—	1	-

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL108358	TIAZOFURIN	IC50	=	260.0	nM	6.58
CHEMBL2158240	—	Activity		-	—	-