Assay Detail
ADMET
CHEMBL2160691
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Cytotoxicity against human MRC5 cells after 72 hrs by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | MRC5 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and in vitro antitumour screening of 2-(β-D-xylofuranosyl)thiazole-4-carboxamide and two novel tiazofurin analogues with substituted tetrahydrofurodioxol moiety as a sugar mimic.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.44 | 6.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL108358 | TIAZOFURIN | 2.0 | 1 | 6.44 |
| CHEMBL2158238 | — | — | 1 | - |
| CHEMBL2158239 | — | — | 1 | - |
| CHEMBL2158240 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL108358 | TIAZOFURIN | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL2158238 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2158239 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2158240 | — | IC50 | > | 100000.0 | nM | - |