Assay Detail
Binding
CHEMBL2160981
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]astemizole from human ERG potassium channel
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Optimization of a potent class of arylamide colony-stimulating factor-1 receptor inhibitors leading to anti-inflammatory clinical candidate 4-cyano-N-[2-(1-cyclohexen-1-yl)-4-[1-[(dimethylamino)acetyl]-4-piperidinyl]phenyl]-1H-imidazole-2-carboxamide (JNJ-28312141).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 5.11 | 5.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2158224 | — | — | 1 | 5.11 |
| CHEMBL2158290 | — | — | 1 | - |
| CHEMBL2158222 | — | — | 1 | - |
| CHEMBL2158223 | — | — | 1 | - |
| CHEMBL2158225 | — | — | 1 | - |
| CHEMBL2158226 | — | — | 1 | - |
| CHEMBL2158227 | — | — | 1 | - |
| CHEMBL2158228 | — | — | 1 | - |
| CHEMBL2158229 | — | — | 1 | - |
| CHEMBL2158230 | — | — | 1 | - |
| CHEMBL256712 | — | — | 1 | - |
| CHEMBL2158231 | — | — | 1 | - |
| CHEMBL1908842 | — | — | 1 | - |
| CHEMBL2158287 | — | — | 1 | - |
| CHEMBL2158288 | — | — | 1 | - |
| CHEMBL2158221 | — | — | 1 | - |
| CHEMBL2158291 | — | — | 1 | - |
| CHEMBL2158292 | — | — | 1 | - |
| CHEMBL2158293 | — | — | 1 | - |
| CHEMBL2158294 | — | — | 1 | - |
| CHEMBL2158295 | — | — | 1 | - |
| CHEMBL2158296 | — | — | 1 | - |
| CHEMBL2158297 | — | — | 1 | - |
| CHEMBL2158298 | — | — | 1 | - |
| CHEMBL2158299 | — | — | 1 | - |
| CHEMBL2158300 | — | — | 1 | - |
| CHEMBL2158301 | — | — | 1 | - |
| CHEMBL2158302 | — | — | 1 | - |
| CHEMBL2158303 | — | — | 1 | - |
| CHEMBL2158289 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2158224 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL2158290 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2158222 | — | IC50 | - | — | - | |
| CHEMBL2158223 | — | IC50 | - | — | - | |
| CHEMBL2158225 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2158226 | — | IC50 | - | — | - | |
| CHEMBL2158227 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2158228 | — | IC50 | - | — | - | |
| CHEMBL2158229 | — | IC50 | - | — | - | |
| CHEMBL2158230 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL256712 | — | IC50 | > | 3200.0 | nM | - |
| CHEMBL2158231 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1908842 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2158287 | — | IC50 | - | — | - | |
| CHEMBL2158288 | — | IC50 | - | — | - | |
| CHEMBL2158221 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2158291 | — | IC50 | - | — | - | |
| CHEMBL2158292 | — | IC50 | - | — | - | |
| CHEMBL2158293 | — | IC50 | - | — | - | |
| CHEMBL2158294 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2158295 | — | IC50 | - | — | - | |
| CHEMBL2158296 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2158297 | — | IC50 | > | 3200.0 | nM | - |
| CHEMBL2158298 | — | IC50 | - | — | - | |
| CHEMBL2158299 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2158300 | — | IC50 | - | — | - | |
| CHEMBL2158301 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2158302 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2158303 | — | IC50 | - | — | - | |
| CHEMBL2158289 | — | IC50 | > | 10000.0 | nM | - |