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Assay Detail

CHEMBL2161546

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of CDK1
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Cyclin-dependent kinase 1 (CHEMBL308)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Identification of pyrimidine derivatives as hSMG-1 inhibitors.
Gopalsamy A, Bennett EM, Shi M, Zhang WG, Bard J, Yu K.
Bioorg Med Chem Lett (2012) 22 : 6636 -6641
PubMed 23021994 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 26 6.66 8.13

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2158853 1 8.13
CHEMBL2158843 1 7.92
CHEMBL2158844 1 7.46
CHEMBL2158857 1 7.44
CHEMBL2158855 1 7.32
CHEMBL2158845 1 7.26
CHEMBL2158858 1 7.21
CHEMBL2158848 1 7.00
CHEMBL2158854 1 7.00
CHEMBL2158859 1 6.68
CHEMBL2158862 1 6.64
CHEMBL2158864 1 6.50
CHEMBL2158861 1 5.92
CHEMBL2158865 1 5.85
CHEMBL2158011 1 5.50
CHEMBL2158863 1 4.85
CHEMBL2158866 1 4.50
CHEMBL2158860 1 -
CHEMBL300389 1 -
CHEMBL2158846 1 -
CHEMBL2158847 1 -
CHEMBL2158849 1 -
CHEMBL2158850 1 -
CHEMBL2158851 1 -
CHEMBL2158852 1 -
CHEMBL2158856 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2158853 IC50 = 7.4 nM 8.13
CHEMBL2158843 IC50 = 12.0 nM 7.92
CHEMBL2158844 IC50 = 35.0 nM 7.46
CHEMBL2158857 IC50 = 36.0 nM 7.44
CHEMBL2158855 IC50 = 48.0 nM 7.32
CHEMBL2158845 IC50 = 55.0 nM 7.26
CHEMBL2158858 IC50 = 62.0 nM 7.21
CHEMBL2158848 IC50 = 100.0 nM 7.00
CHEMBL2158854 IC50 = 100.0 nM 7.00
CHEMBL2158859 IC50 = 210.0 nM 6.68
CHEMBL2158862 IC50 = 230.0 nM 6.64
CHEMBL2158864 IC50 = 320.0 nM 6.50
CHEMBL2158861 IC50 = 1200.0 nM 5.92
CHEMBL2158865 IC50 = 1400.0 nM 5.85
CHEMBL2158011 IC50 = 3200.0 nM 5.50
CHEMBL2158863 IC50 = 14000.0 nM 4.85
CHEMBL2158866 IC50 = 32000.0 nM 4.50
CHEMBL2158860 IC50 - -
CHEMBL300389 IC50 < 5.2 nM -
CHEMBL2158846 IC50 - -
CHEMBL2158847 IC50 - -
CHEMBL2158849 IC50 - -
CHEMBL2158850 IC50 - -
CHEMBL2158851 IC50 - -
CHEMBL2158852 IC50 - -
CHEMBL2158856 IC50 - -