Assay Detail
Functional
CHEMBL2161729
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Antiproliferative activity against human SKOV3 cells with mixed population of 25% NTR(+) cells and 75% NTR(-) cells assessed as reduction in cell number after 18 hrs
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-OV-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of nitrobenzyl phosphoramide mustards as nitroreductase-activated prodrugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.15 | 6.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1256991 | — | — | 1 | 6.43 |
| CHEMBL1256990 | — | — | 1 | 6.32 |
| CHEMBL1257017 | — | — | 1 | 6.27 |
| CHEMBL144896 | — | — | 1 | 6.01 |
| CHEMBL1257016 | — | — | 1 | 6.00 |
| CHEMBL1257018 | — | — | 1 | 5.86 |
| CHEMBL1256965 | — | — | 1 | - |
| CHEMBL1256966 | — | — | 1 | - |
| CHEMBL1256989 | — | — | 1 | - |
| CHEMBL2158184 | — | — | 1 | - |
| CHEMBL2158185 | — | — | 1 | - |
| CHEMBL2158186 | — | — | 1 | - |
| CHEMBL2158187 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1256991 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL1256990 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL1257017 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL144896 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL1257016 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL1257018 | — | IC50 | = | 1370.0 | nM | 5.86 |
| CHEMBL1256965 | — | IC50 | - | — | - | |
| CHEMBL1256966 | — | IC50 | - | — | - | |
| CHEMBL1256989 | — | IC50 | - | — | - | |
| CHEMBL2158184 | — | IC50 | - | — | - | |
| CHEMBL2158185 | — | IC50 | - | — | - | |
| CHEMBL2158186 | — | IC50 | - | — | - | |
| CHEMBL2158187 | — | IC50 | - | — | - |