Assay Detail
Binding
CHEMBL2162066
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of self-mediated amyloid beta (1 to 42) aggregation after 10 hrs by thioflavin-T based fluorometric assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis, and bioevaluation of benzamides: novel acetylcholinesterase inhibitors with multi-functions on butylcholinesterase, Aβ aggregation, and β-secretase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.38 | 4.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 4.98 |
| CHEMBL2159661 | — | — | 1 | 4.30 |
| CHEMBL2159660 | — | — | 1 | 4.15 |
| CHEMBL2159662 | — | — | 1 | 4.10 |
| CHEMBL2159663 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL140 | CURCUMIN | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL2159661 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL2159660 | — | IC50 | = | 71000.0 | nM | 4.15 |
| CHEMBL2159662 | — | IC50 | = | 79000.0 | nM | 4.10 |
| CHEMBL2159663 | — | IC50 | > | 250000.0 | nM | - |