Assay Detail
Binding
CHEMBL2162509
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-N-methylspiperone from human dopamine D2long receptor expressed in HEK293 cells after 30 mins by scintillation counting
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of a 2-phenyl-substituted octahydrobenzo[f]quinoline as a dopamine D₃ receptor-selective full agonist ligand.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.90 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL71 | CHLORPROMAZINE | 4.0 | 1 | 8.92 |
| CHEMBL2158640 | — | — | 1 | 6.80 |
| CHEMBL1224527 | — | — | 1 | 6.64 |
| CHEMBL2158636 | — | — | 1 | 6.31 |
| CHEMBL1255966 | — | — | 1 | 5.84 |
| CHEMBL2158641 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL71 | CHLORPROMAZINE | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL2158640 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL1224527 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL2158636 | — | Ki | = | 490.0 | nM | 6.31 |
| CHEMBL1255966 | — | Ki | = | 1430.0 | nM | 5.84 |
| CHEMBL2158641 | — | Ki | - | — | - |