Assay Detail
Binding
CHEMBL2162511
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Displacement of [3H]-N-methylspiperone from dopamine D2 like receptor in pig striatal homogenates after 30 mins by scintillation counting
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Identification of a 2-phenyl-substituted octahydrobenzo[f]quinoline as a dopamine D₃ receptor-selective full agonist ligand.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.42 | 8.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL71 | CHLORPROMAZINE | 4.0 | 1 | 8.39 |
| CHEMBL2158640 | — | — | 1 | 8.00 |
| CHEMBL2158636 | — | — | 1 | 7.85 |
| CHEMBL2158637 | — | — | 1 | 7.54 |
| CHEMBL2158642 | — | — | 1 | 7.52 |
| CHEMBL2158638 | — | — | 1 | 7.25 |
| CHEMBL2158639 | — | — | 1 | 6.82 |
| CHEMBL1224527 | — | — | 1 | 6.75 |
| CHEMBL25856 | DIHYDREXIDINE | 2.0 | 1 | 6.70 |
| CHEMBL2158641 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL71 | CHLORPROMAZINE | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL2158640 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL2158636 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL2158637 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL2158642 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL2158638 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL2158639 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL1224527 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL25856 | DIHYDREXIDINE | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL2158641 | — | Ki | - | — | - |