Assay Detail
Binding
CHEMBL2162787
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Transactivation of GAL4-fused PPARbeta (delta) ligand binding domain transfected in human HepG2 cells after 20 hrs by luciferase reporter gene assay
13
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor delta (CHEMBL3979) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Diarylheptanoid glycosides from Tacca plantaginea and their effects on NF-κB activation and PPAR transcriptional activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 4.93 | 6.19 |
| Activity | 6 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL153057 | — | — | 1 | 6.19 |
| CHEMBL2159605 | PLANTAGINEOSIDE A | — | 2 | 4.96 |
| CHEMBL2159606 | PLANTAGINEOSIDE B | — | 2 | 4.88 |
| CHEMBL458899 | — | — | 2 | 4.81 |
| CHEMBL465800 | — | — | 2 | 4.64 |
| CHEMBL516827 | — | — | 2 | 4.53 |
| CHEMBL2159607 | PLANTAGINEOSIDE C | — | 2 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL153057 | — | EC50 | = | 650.0 | nM | 6.19 |
| CHEMBL2159605 | PLANTAGINEOSIDE A | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL2159606 | PLANTAGINEOSIDE B | EC50 | = | 13100.0 | nM | 4.88 |
| CHEMBL458899 | — | EC50 | = | 15600.0 | nM | 4.81 |
| CHEMBL465800 | — | EC50 | = | 23100.0 | nM | 4.64 |
| CHEMBL516827 | — | EC50 | = | 29300.0 | nM | 4.53 |
| CHEMBL2159607 | PLANTAGINEOSIDE C | EC50 | = | 30100.0 | nM | 4.52 |
| CHEMBL465800 | — | Activity | - | — | - | |
| CHEMBL458899 | — | Activity | - | — | - | |
| CHEMBL516827 | — | Activity | - | — | - | |
| CHEMBL2159607 | PLANTAGINEOSIDE C | Activity | - | — | - | |
| CHEMBL2159606 | PLANTAGINEOSIDE B | Activity | - | — | - | |
| CHEMBL2159605 | PLANTAGINEOSIDE A | Activity | - | — | - |