Assay Detail
Binding
CHEMBL2162808
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant His-tagged SENP1 catalytic domain expressed in Escherichia coli BL21(DE3) using His-tagged deltaRanGAP-SUMO2 as substrate incubated for 10 mins prior to substrate addition measured after 45 mins by SDS-PAGE analysis
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
2-(4-Chlorophenyl)-2-oxoethyl 4-benzamidobenzoate derivatives, a novel class of SENP1 inhibitors: Virtual screening, synthesis and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.74 | 5.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2159857 | — | — | 1 | 5.97 |
| CHEMBL2159858 | — | — | 1 | 5.93 |
| CHEMBL2159859 | — | — | 1 | 5.76 |
| CHEMBL2159862 | — | — | 1 | 5.73 |
| CHEMBL2159861 | — | — | 1 | 5.62 |
| CHEMBL2159860 | — | — | 1 | 5.45 |
| CHEMBL2159852 | — | — | 1 | - |
| CHEMBL2159854 | — | — | 1 | - |
| CHEMBL2159856 | — | — | 1 | - |
| CHEMBL2159855 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2159857 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL2159858 | — | IC50 | = | 1175.0 | nM | 5.93 |
| CHEMBL2159859 | — | IC50 | = | 1735.0 | nM | 5.76 |
| CHEMBL2159862 | — | IC50 | = | 1856.0 | nM | 5.73 |
| CHEMBL2159861 | — | IC50 | = | 2385.0 | nM | 5.62 |
| CHEMBL2159860 | — | IC50 | = | 3542.0 | nM | 5.45 |
| CHEMBL2159852 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2159854 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2159856 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2159855 | — | IC50 | > | 50000.0 | nM | - |