Assay Detail
Binding
CHEMBL2162864
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Inhibition of recombinant USP7 expressed in Sf9 cells by Ub-CHOP reporter assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Sf9 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Ubiquitin carboxyl-terminal hydrolase 7 (CHEMBL2157850) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Selective Dual Inhibitors of the Cancer-Related Deubiquitylating Proteases USP7 and USP47.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.74 | 6.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2159503 | — | — | 1 | 6.42 |
| CHEMBL2159507 | — | — | 1 | 6.42 |
| CHEMBL2159505 | — | — | 1 | 6.40 |
| CHEMBL2159508 | — | — | 1 | 6.38 |
| CHEMBL2159504 | — | — | 1 | 6.37 |
| CHEMBL2159501 | — | — | 1 | 5.77 |
| CHEMBL2159499 | — | — | 1 | 5.66 |
| CHEMBL2159495 | — | — | 1 | 5.38 |
| CHEMBL2159497 | — | — | 1 | 5.16 |
| CHEMBL2159502 | — | — | 1 | 5.11 |
| CHEMBL2159498 | — | — | 1 | 5.10 |
| CHEMBL2159506 | — | — | 1 | 4.72 |
| CHEMBL2159496 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2159503 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL2159507 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL2159505 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL2159508 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL2159504 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL2159501 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL2159499 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL2159495 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL2159497 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL2159502 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL2159498 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL2159506 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL2159496 | — | IC50 | > | 31600.0 | nM | - |