Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL2166096

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]-5-CT from human cloned 5HT7 receptor
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

5-hydroxytryptamine receptor 7 (CHEMBL3155)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Investigations on the 1-(2-biphenyl)piperazine motif: identification of new potent and selective ligands for the serotonin(7) (5-HT(7)) receptor with agonist or antagonist action in vitro or ex vivo.
Lacivita E, Patarnello D, Stroth N, Caroli A, Niso M, Contino M, De Giorgio P, Di Pilato P, Colabufo NA, Berardi F, Perrone R, Svenningsson P, Hedlund PB, Leopoldo M.
J Med Chem (2012) 55 : 6375 -6380
PubMed 22738316 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 20 8.02 9.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1256863 1 9.52
CHEMBL2164330 1 8.85
CHEMBL494675 1 8.85
CHEMBL2164334 1 8.72
CHEMBL2164336 1 8.59
CHEMBL2164332 1 8.57
CHEMBL2164329 1 8.16
CHEMBL2164338 1 8.15
CHEMBL2164343 1 8.15
CHEMBL2164328 1 8.09
CHEMBL2164339 1 7.89
CHEMBL522691 1 7.82
CHEMBL2164344 1 7.74
CHEMBL2164340 1 7.64
CHEMBL2164331 1 7.60
CHEMBL2164341 1 7.10
CHEMBL2164335 1 7.03
CHEMBL2164342 1 7.02
CHEMBL2164333 1 6.96
CHEMBL2164337 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1256863 Ki = 0.3 nM 9.52
CHEMBL2164330 Ki = 1.4 nM 8.85
CHEMBL494675 Ki = 1.4 nM 8.85
CHEMBL2164334 Ki = 1.9 nM 8.72
CHEMBL2164336 Ki = 2.6 nM 8.59
CHEMBL2164332 Ki = 2.7 nM 8.57
CHEMBL2164329 Ki = 6.9 nM 8.16
CHEMBL2164338 Ki = 7.0 nM 8.15
CHEMBL2164343 Ki = 7.1 nM 8.15
CHEMBL2164328 Ki = 8.2 nM 8.09
CHEMBL2164339 Ki = 13.0 nM 7.89
CHEMBL522691 Ki = 15.0 nM 7.82
CHEMBL2164344 Ki = 18.4 nM 7.74
CHEMBL2164340 Ki = 23.0 nM 7.64
CHEMBL2164331 Ki = 25.0 nM 7.60
CHEMBL2164341 Ki = 80.0 nM 7.10
CHEMBL2164335 Ki = 93.0 nM 7.03
CHEMBL2164342 Ki = 96.0 nM 7.02
CHEMBL2164333 Ki = 109.0 nM 6.96
CHEMBL2164337 Ki > 5000.0 nM -