Assay Detail
Binding
CHEMBL2166347
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Inhibition of human CYP11B2 expressed in V79MZh cells using [14C]-11-deoxycorticosterone as substrate by HPTLC/phosphoimaging method
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | V79MZh |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Selective dual inhibitors of CYP19 and CYP11B2: targeting cardiovascular diseases hiding in the shadow of breast cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.90 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9298 | FADROZOLE | 2.0 | 1 | 9.10 |
| CHEMBL2165322 | — | — | 1 | 7.92 |
| CHEMBL2165317 | — | — | 1 | 7.72 |
| CHEMBL2165315 | — | — | 1 | 7.72 |
| CHEMBL2165320 | — | — | 1 | 7.66 |
| CHEMBL2165321 | — | — | 1 | 6.75 |
| CHEMBL2165325 | — | — | 1 | 6.68 |
| CHEMBL2165314 | — | — | 1 | 6.57 |
| CHEMBL2165313 | — | — | 1 | 6.51 |
| CHEMBL2165316 | — | — | 1 | 6.17 |
| CHEMBL2165319 | — | — | 1 | 6.12 |
| CHEMBL2165324 | — | — | 1 | 5.96 |
| CHEMBL2165323 | — | — | 1 | 5.93 |
| CHEMBL2165318 | — | — | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9298 | FADROZOLE | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL2165322 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2165317 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL2165315 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL2165320 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL2165321 | — | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL2165325 | — | IC50 | = | 208.0 | nM | 6.68 |
| CHEMBL2165314 | — | IC50 | = | 268.0 | nM | 6.57 |
| CHEMBL2165313 | — | IC50 | = | 312.0 | nM | 6.51 |
| CHEMBL2165316 | — | IC50 | = | 674.0 | nM | 6.17 |
| CHEMBL2165319 | — | IC50 | = | 759.0 | nM | 6.12 |
| CHEMBL2165324 | — | IC50 | = | 1097.0 | nM | 5.96 |
| CHEMBL2165323 | — | IC50 | = | 1167.0 | nM | 5.93 |
| CHEMBL2165318 | — | IC50 | = | 1703.0 | nM | 5.77 |