Assay Detail
Functional
CHEMBL2166482
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Growth inhibition of human OE33 cells after 3 days by MTT assay
49
Total Activities
49
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | OE33 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel trisubstituted harmine derivatives with original in vitro anticancer activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 49 | 5.28 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2164703 | — | — | 1 | 6.60 |
| CHEMBL2164702 | — | — | 1 | 6.52 |
| CHEMBL2164697 | — | — | 1 | 6.46 |
| CHEMBL2164696 | — | — | 1 | 6.43 |
| CHEMBL2164717 | — | — | 1 | 6.16 |
| CHEMBL2164716 | — | — | 1 | 6.16 |
| CHEMBL2164704 | — | — | 1 | 6.00 |
| CHEMBL2164698 | — | — | 1 | 6.00 |
| CHEMBL2164693 | — | — | 1 | 5.85 |
| CHEMBL2164694 | — | — | 1 | 5.80 |
| CHEMBL2164718 | — | — | 1 | 5.62 |
| CHEMBL2164404 | — | — | 1 | 5.54 |
| CHEMBL2164691 | — | — | 1 | 5.52 |
| CHEMBL2164695 | — | — | 1 | 5.51 |
| CHEMBL2164692 | — | — | 1 | 5.47 |
| CHEMBL1645549 | — | — | 1 | 5.39 |
| CHEMBL2164715 | — | — | 1 | 5.26 |
| CHEMBL1645553 | — | — | 1 | 5.20 |
| CHEMBL1645550 | — | — | 1 | 5.10 |
| CHEMBL2164707 | — | — | 1 | 5.09 |
| CHEMBL1645548 | — | — | 1 | 5.09 |
| CHEMBL2164714 | — | — | 1 | 5.05 |
| CHEMBL2164712 | — | — | 1 | 4.82 |
| CHEMBL2164710 | — | — | 1 | 4.80 |
| CHEMBL269538 | HARMINE | 1.0 | 1 | 4.75 |
| CHEMBL1645551 | — | — | 1 | 4.64 |
| CHEMBL1645545 | — | — | 1 | 4.60 |
| CHEMBL2164711 | — | — | 1 | 4.60 |
| CHEMBL1645544 | — | — | 1 | 4.52 |
| CHEMBL1645552 | — | — | 1 | 4.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2164703 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL2164702 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2164697 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL2164696 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL2164717 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL2164716 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL2164704 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2164698 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2164693 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL2164694 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL2164718 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL2164404 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL2164691 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL2164695 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL2164692 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL1645549 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL2164715 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL1645553 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL1645550 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL2164707 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL1645548 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL2164714 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL2164712 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL2164710 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL269538 | HARMINE | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL1645551 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL1645545 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL2164711 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL1645544 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL1645552 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL2164706 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL2164708 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL2164709 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL14355 | — | IC50 | = | 63000.0 | nM | 4.20 |
| CHEMBL1645546 | — | IC50 | = | 66000.0 | nM | 4.18 |
| CHEMBL2164720 | — | IC50 | - | — | - | |
| CHEMBL2164401 | — | IC50 | - | — | - | |
| CHEMBL2164402 | — | IC50 | - | — | - | |
| CHEMBL2164713 | — | IC50 | - | — | - | |
| CHEMBL2164403 | — | IC50 | - | — | - | |
| CHEMBL2164699 | — | IC50 | - | — | - | |
| CHEMBL2164700 | — | IC50 | - | — | - | |
| CHEMBL2164701 | — | IC50 | - | — | - | |
| CHEMBL2164705 | — | IC50 | - | — | - | |
| CHEMBL2164398 | — | IC50 | - | — | - | |
| CHEMBL2164399 | — | IC50 | - | — | - | |
| CHEMBL1645547 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2164719 | — | IC50 | - | — | - | |
| CHEMBL2164400 | — | IC50 | - | — | - |