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Assay Detail

CHEMBL2166483

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Functional
Growth inhibition of human Hs 683 cells after 3 days by MTT assay
ChEMBL ↗
49
Total Activities
49
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type Hs 683
Confidence 1 — Organism
Curated By Autocuration

Target

Hs 683 (CHEMBL612596) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Novel trisubstituted harmine derivatives with original in vitro anticancer activity.
Frédérick R, Bruyère C, Vancraeynest C, Reniers J, Meinguet C, Pochet L, Backlund A, Masereel B, Kiss R, Wouters J.
J Med Chem (2012) 55 : 6489 -6501
PubMed 22770529 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 49 5.34 6.60

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2164697 — — 1 6.60
CHEMBL2164700 — — 1 6.58
CHEMBL2164400 — — 1 6.51
CHEMBL2164402 — — 1 6.43
CHEMBL2164696 — — 1 6.42
CHEMBL2164399 — — 1 6.38
CHEMBL2164717 — — 1 6.36
CHEMBL2164703 — — 1 6.35
CHEMBL2164705 — — 1 6.33
CHEMBL2164716 — — 1 6.30
CHEMBL2164720 — — 1 6.22
CHEMBL2164401 — — 1 6.22
CHEMBL2164693 — — 1 6.05
CHEMBL2164694 — — 1 5.92
CHEMBL2164718 — — 1 5.80
CHEMBL2164691 — — 1 5.66
CHEMBL2164719 — — 1 5.64
CHEMBL2164702 — — 1 5.58
CHEMBL2164404 — — 1 5.55
CHEMBL2164698 — — 1 5.51
CHEMBL2164701 — — 1 5.51
CHEMBL2164704 — — 1 5.51
CHEMBL2164715 — — 1 5.44
CHEMBL2164398 — — 1 5.42
CHEMBL2164699 — — 1 5.40
CHEMBL2164692 — — 1 5.35
CHEMBL1645553 — — 1 5.09
CHEMBL2164714 — — 1 4.89
CHEMBL2164695 — — 1 4.89
CHEMBL1645549 — — 1 4.77

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2164697 — IC50 = 250.0 nM 6.60
CHEMBL2164700 — IC50 = 260.0 nM 6.58
CHEMBL2164400 — IC50 = 310.0 nM 6.51
CHEMBL2164402 — IC50 = 370.0 nM 6.43
CHEMBL2164696 — IC50 = 380.0 nM 6.42
CHEMBL2164399 — IC50 = 420.0 nM 6.38
CHEMBL2164717 — IC50 = 440.0 nM 6.36
CHEMBL2164703 — IC50 = 450.0 nM 6.35
CHEMBL2164705 — IC50 = 470.0 nM 6.33
CHEMBL2164716 — IC50 = 500.0 nM 6.30
CHEMBL2164720 — IC50 = 600.0 nM 6.22
CHEMBL2164401 — IC50 = 600.0 nM 6.22
CHEMBL2164693 — IC50 = 900.0 nM 6.05
CHEMBL2164694 — IC50 = 1200.0 nM 5.92
CHEMBL2164718 — IC50 = 1600.0 nM 5.80
CHEMBL2164691 — IC50 = 2200.0 nM 5.66
CHEMBL2164719 — IC50 = 2300.0 nM 5.64
CHEMBL2164702 — IC50 = 2600.0 nM 5.58
CHEMBL2164404 — IC50 = 2800.0 nM 5.55
CHEMBL2164698 — IC50 = 3100.0 nM 5.51
CHEMBL2164701 — IC50 = 3100.0 nM 5.51
CHEMBL2164704 — IC50 = 3100.0 nM 5.51
CHEMBL2164715 — IC50 = 3600.0 nM 5.44
CHEMBL2164398 — IC50 = 3800.0 nM 5.42
CHEMBL2164699 — IC50 = 4000.0 nM 5.40
CHEMBL2164692 — IC50 = 4500.0 nM 5.35
CHEMBL1645553 — IC50 = 8100.0 nM 5.09
CHEMBL2164714 — IC50 = 13000.0 nM 4.89
CHEMBL2164695 — IC50 = 13000.0 nM 4.89
CHEMBL1645549 — IC50 = 17000.0 nM 4.77
CHEMBL2164711 — IC50 = 17000.0 nM 4.77
CHEMBL2164710 — IC50 = 18000.0 nM 4.75
CHEMBL2164707 — IC50 = 19000.0 nM 4.72
CHEMBL1645551 — IC50 = 20000.0 nM 4.70
CHEMBL1645550 — IC50 = 21000.0 nM 4.68
CHEMBL1645548 — IC50 = 22000.0 nM 4.66
CHEMBL1645545 — IC50 = 23000.0 nM 4.64
CHEMBL1645544 — IC50 = 28000.0 nM 4.55
CHEMBL2164712 — IC50 = 30000.0 nM 4.52
CHEMBL2164713 — IC50 = 30000.0 nM 4.52
CHEMBL1645552 — IC50 = 30000.0 nM 4.52
CHEMBL2164403 — IC50 = 31000.0 nM 4.51
CHEMBL2164709 — IC50 = 33000.0 nM 4.48
CHEMBL269538 HARMINE IC50 = 37000.0 nM 4.43
CHEMBL14355 — IC50 = 41000.0 nM 4.39
CHEMBL1645546 — IC50 = 53000.0 nM 4.28
CHEMBL2164706 — IC50 = 53000.0 nM 4.28
CHEMBL2164708 — IC50 = 79000.0 nM 4.10
CHEMBL1645547 — IC50 > 100000.0 nM -