Assay Detail
Functional
CHEMBL2166567
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Agonist activity at GPR120 assessed as stimulation of calcium mobilization
9
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Free fatty acid receptor 1 (FFA1/GPR40) agonists: mesylpropoxy appendage lowers lipophilicity and improves ADME properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 4.87 | 5.37 |
| pEC50 | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2164240 | — | — | 1 | 5.37 |
| CHEMBL1773261 | — | — | 1 | 5.20 |
| CHEMBL1688473 | — | — | 1 | 5.08 |
| CHEMBL2164239 | — | — | 1 | 5.07 |
| CHEMBL2163924 | — | — | 1 | 4.96 |
| CHEMBL2164242 | — | — | 1 | 4.36 |
| CHEMBL2164241 | — | — | 1 | 4.03 |
| CHEMBL2163925 | — | — | 1 | - |
| CHEMBL2163923 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2164240 | — | EC50 | = | 4265.8 | nM | 5.37 |
| CHEMBL1773261 | — | EC50 | = | 6309.57 | nM | 5.20 |
| CHEMBL1688473 | — | EC50 | = | 8317.64 | nM | 5.08 |
| CHEMBL2164239 | — | EC50 | = | 8511.38 | nM | 5.07 |
| CHEMBL2163924 | — | EC50 | = | 10964.78 | nM | 4.96 |
| CHEMBL2164242 | — | EC50 | = | 43651.58 | nM | 4.36 |
| CHEMBL2164241 | — | EC50 | = | 93325.43 | nM | 4.03 |
| CHEMBL2163925 | — | pEC50 | - | — | - | |
| CHEMBL2163923 | — | pEC50 | - | — | - |