Assay Detail
Binding
CHEMBL2166697
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Binding affinity to human 5-HT6 receptor
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
N,N-Dimethyl-[9-(arylsulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl]amines as novel, potent and selective 5-HT₆ receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.35 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL361213 | — | — | 1 | 8.85 |
| CHEMBL2165520 | — | — | 1 | 8.80 |
| CHEMBL92093 | — | — | 1 | 8.64 |
| CHEMBL76237 | — | — | 1 | 8.64 |
| CHEMBL127411 | — | — | 1 | 8.14 |
| CHEMBL2165522 | — | — | 1 | 7.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL361213 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL2165520 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL92093 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL76237 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL127411 | — | Ki | = | 7.2 | nM | 8.14 |
| CHEMBL2165522 | — | Ki | = | 96.0 | nM | 7.02 |