Assay Detail
Functional
CHEMBL2166793
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Agonist activity at human NPFF2 receptor F/Y7.35A mutant assessed as [3H]inositol phosphate accumulation after 2 hrs by liquid scintillation counting
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Selective mode of action of guanidine-containing non-peptides at human NPFF receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.52 | 6.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL332347 | — | — | 1 | 6.95 |
| CHEMBL429731 | — | — | 1 | 6.92 |
| CHEMBL2165922 | — | — | 1 | 6.52 |
| CHEMBL1672380 | — | — | 1 | 6.33 |
| CHEMBL2165921 | — | — | 1 | 5.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL332347 | — | EC50 | = | 113.0 | nM | 6.95 |
| CHEMBL429731 | — | EC50 | = | 119.0 | nM | 6.92 |
| CHEMBL2165922 | — | EC50 | = | 301.0 | nM | 6.52 |
| CHEMBL1672380 | — | EC50 | = | 472.0 | nM | 6.33 |
| CHEMBL2165921 | — | EC50 | = | 1256.0 | nM | 5.90 |