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Assay Detail

CHEMBL2166949

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to rat forebrain alpha7* nACHR at 10 uM
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Identification of novel α4β2-nicotinic acetylcholine receptor (nAChR) agonists based on an isoxazole ether scaffold that demonstrate antidepressant-like activity.
Yu LF, Tückmantel W, Eaton JB, Caldarone B, Fedolak A, Hanania T, Brunner D, Lukas RJ, Kozikowski AP.
J Med Chem (2012) 55 : 812 -823
PubMed 22148173 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 12 5.17 5.17

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2165444 1 5.17
CHEMBL3 NICOTINE 4.0 1 -
CHEMBL2165445 1 -
CHEMBL2165443 1 -
CHEMBL2165442 1 -
CHEMBL2165441 1 -
CHEMBL2165440 1 -
CHEMBL2165439 1 -
CHEMBL2165438 1 -
CHEMBL2165453 1 -
CHEMBL2165452 1 -
CHEMBL2165451 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2165444 Ki = 6790.0 nM 5.17
CHEMBL3 NICOTINE Ki - -
CHEMBL2165445 Ki - -
CHEMBL2165443 Ki - -
CHEMBL2165442 Ki - -
CHEMBL2165441 Ki - -
CHEMBL2165440 Ki - -
CHEMBL2165439 Ki - -
CHEMBL2165438 Ki - -
CHEMBL2165453 Ki - -
CHEMBL2165452 Ki - -
CHEMBL2165451 Ki - -