Assay Detail
Functional
CHEMBL2167057
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Cytotoxicity against human SKBR3 cells after 2 hrs by methylene blue staining-based spectrophotometric analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-BR-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antitumor agents 295. E-ring hydroxylated antofine and cryptopleurine analogues as antiproliferative agents: design, synthesis, and mechanistic studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.16 | 7.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2164800 | — | — | 1 | 7.14 |
| CHEMBL2164799 | — | — | 1 | 6.53 |
| CHEMBL2164802 | — | — | 1 | 6.46 |
| CHEMBL2164801 | — | — | 1 | 5.48 |
| CHEMBL2164803 | — | — | 1 | 5.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2164800 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL2164799 | — | IC50 | = | 295.0 | nM | 6.53 |
| CHEMBL2164802 | — | IC50 | = | 348.0 | nM | 6.46 |
| CHEMBL2164801 | — | IC50 | = | 3340.0 | nM | 5.48 |
| CHEMBL2164803 | — | IC50 | = | 6440.0 | nM | 5.19 |