Assay Detail
Functional
CHEMBL2167058
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Cytotoxicity against human KB cells after 2 hrs by methylene blue staining-based spectrophotometric analysis
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antitumor agents 295. E-ring hydroxylated antofine and cryptopleurine analogues as antiproliferative agents: design, synthesis, and mechanistic studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.49 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL198075 | CRYPTOPLEURINE | — | 1 | 8.82 |
| CHEMBL2164800 | — | — | 1 | 7.64 |
| CHEMBL2164804 | — | — | 1 | 7.60 |
| CHEMBL2164802 | — | — | 1 | 7.48 |
| CHEMBL228286 | (-)-ANTOFINE | — | 1 | 7.44 |
| CHEMBL2164799 | — | — | 1 | 7.37 |
| CHEMBL2164798 | — | — | 1 | 7.30 |
| CHEMBL2164791 | — | — | 1 | 7.00 |
| CHEMBL2164805 | — | — | 1 | 6.52 |
| CHEMBL2164795 | — | — | 1 | 6.30 |
| CHEMBL2164793 | — | — | 1 | 6.30 |
| CHEMBL2164801 | — | — | 1 | 6.13 |
| CHEMBL2164796 | — | — | 1 | 6.11 |
| CHEMBL2164806 | — | — | 1 | 6.08 |
| CHEMBL2164808 | — | — | 1 | 6.04 |
| CHEMBL2164797 | — | — | 1 | 5.74 |
| CHEMBL2164792 | — | — | 1 | 5.74 |
| CHEMBL2164803 | — | — | 1 | 5.65 |
| CHEMBL2164809 | — | — | 1 | 5.28 |
| CHEMBL2164794 | — | — | 1 | 4.92 |
| CHEMBL2164807 | — | — | 1 | 4.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL198075 | CRYPTOPLEURINE | IC50 | = | 1.51 | nM | 8.82 |
| CHEMBL2164800 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL2164804 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL2164802 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL228286 | (-)-ANTOFINE | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL2164799 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL2164798 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL2164791 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2164805 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2164795 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL2164793 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL2164801 | — | IC50 | = | 734.0 | nM | 6.13 |
| CHEMBL2164796 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL2164806 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL2164808 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL2164797 | — | IC50 | = | 1810.0 | nM | 5.74 |
| CHEMBL2164792 | — | IC50 | = | 1830.0 | nM | 5.74 |
| CHEMBL2164803 | — | IC50 | = | 2250.0 | nM | 5.65 |
| CHEMBL2164809 | — | IC50 | = | 5240.0 | nM | 5.28 |
| CHEMBL2164794 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL2164807 | — | IC50 | = | 17520.0 | nM | 4.76 |