Assay Detail
Functional
CHEMBL2167061
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Cytotoxicity against human A549 cells after 2 hrs by methylene blue staining-based spectrophotometric analysis
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antitumor agents 295. E-ring hydroxylated antofine and cryptopleurine analogues as antiproliferative agents: design, synthesis, and mechanistic studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.59 | 8.86 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL198075 | CRYPTOPLEURINE | — | 1 | 8.86 |
| CHEMBL2164804 | — | — | 1 | 8.00 |
| CHEMBL228286 | (-)-ANTOFINE | — | 1 | 7.66 |
| CHEMBL2164800 | — | — | 1 | 7.66 |
| CHEMBL2164791 | — | — | 1 | 7.60 |
| CHEMBL2164798 | — | — | 1 | 7.55 |
| CHEMBL2164805 | — | — | 1 | 7.16 |
| CHEMBL2164799 | — | — | 1 | 7.14 |
| CHEMBL2164802 | — | — | 1 | 7.09 |
| CHEMBL2164793 | — | — | 1 | 6.57 |
| CHEMBL2164795 | — | — | 1 | 6.54 |
| CHEMBL2164806 | — | — | 1 | 6.26 |
| CHEMBL2164796 | — | — | 1 | 6.21 |
| CHEMBL2164801 | — | — | 1 | 6.04 |
| CHEMBL2164808 | — | — | 1 | 6.00 |
| CHEMBL2164797 | — | — | 1 | 5.64 |
| CHEMBL2164803 | — | — | 1 | 5.60 |
| CHEMBL2164792 | — | — | 1 | 5.55 |
| CHEMBL2164794 | — | — | 1 | 5.22 |
| CHEMBL2164809 | — | — | 1 | 5.15 |
| CHEMBL2164807 | — | — | 1 | 4.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL198075 | CRYPTOPLEURINE | IC50 | = | 1.38 | nM | 8.86 |
| CHEMBL2164804 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL228286 | (-)-ANTOFINE | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL2164800 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL2164791 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL2164798 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL2164805 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL2164799 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL2164802 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL2164793 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL2164795 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL2164806 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL2164796 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL2164801 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL2164808 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL2164797 | — | IC50 | = | 2270.0 | nM | 5.64 |
| CHEMBL2164803 | — | IC50 | = | 2510.0 | nM | 5.60 |
| CHEMBL2164792 | — | IC50 | = | 2810.0 | nM | 5.55 |
| CHEMBL2164794 | — | IC50 | = | 5970.0 | nM | 5.22 |
| CHEMBL2164809 | — | IC50 | = | 7110.0 | nM | 5.15 |
| CHEMBL2164807 | — | IC50 | = | 14480.0 | nM | 4.84 |