Assay Detail
Binding
CHEMBL2167302
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL2-DE3 incubated 10 mins before substrate addition by fluorescence spectrophotometry based cell free system assay
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL215) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Dynamic modeling of human 5-lipoxygenase-inhibitor interactions helps to discover novel inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 4.95 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL300982 | LICOFELONE | 2.0 | 1 | 6.75 |
| CHEMBL2163386 | — | — | 1 | 6.21 |
| CHEMBL2163385 | — | — | 1 | 6.10 |
| CHEMBL2163384 | — | — | 1 | 6.07 |
| CHEMBL2163347 | — | — | 1 | 5.98 |
| CHEMBL93 | ZILEUTON | 4.0 | 1 | 5.96 |
| CHEMBL2163383 | — | — | 1 | 5.85 |
| CHEMBL2163382 | — | — | 1 | 5.83 |
| CHEMBL2163381 | — | — | 1 | 5.73 |
| CHEMBL2163379 | — | — | 1 | 5.34 |
| CHEMBL2163380 | — | — | 1 | 5.28 |
| CHEMBL2163378 | — | — | 1 | 5.27 |
| CHEMBL2163377 | — | — | 1 | 5.16 |
| CHEMBL2163376 | — | — | 1 | 4.85 |
| CHEMBL2163375 | — | — | 1 | 4.82 |
| CHEMBL2163374 | — | — | 1 | 4.77 |
| CHEMBL2163373 | — | — | 1 | 4.70 |
| CHEMBL2165874 | — | — | 1 | 4.54 |
| CHEMBL2165873 | — | — | 1 | 4.47 |
| CHEMBL2165872 | — | — | 1 | 4.43 |
| CHEMBL2165871 | — | — | 1 | 4.36 |
| CHEMBL1555743 | — | — | 1 | 4.35 |
| CHEMBL2165870 | — | — | 1 | 4.28 |
| CHEMBL2165869 | — | — | 1 | 4.19 |
| CHEMBL2165868 | — | — | 1 | 4.17 |
| CHEMBL2165866 | — | — | 1 | 4.17 |
| CHEMBL2165867 | — | — | 1 | 4.16 |
| CHEMBL2165865 | — | — | 1 | 4.16 |
| CHEMBL2165863 | — | — | 1 | 4.10 |
| CHEMBL2165864 | — | — | 1 | 4.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL300982 | LICOFELONE | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL2163386 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL2163385 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL2163384 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL2163347 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL93 | ZILEUTON | IC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL2163383 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL2163382 | — | IC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL2163381 | — | IC50 | = | 1870.0 | nM | 5.73 |
| CHEMBL2163379 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL2163380 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL2163378 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL2163377 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL2163376 | — | IC50 | = | 14200.0 | nM | 4.85 |
| CHEMBL2163375 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL2163374 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL2163373 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL2165874 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL2165873 | — | IC50 | = | 33800.0 | nM | 4.47 |
| CHEMBL2165872 | — | IC50 | = | 37500.0 | nM | 4.43 |
| CHEMBL2165871 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL1555743 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL2165870 | — | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL2165869 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL2165868 | — | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL2165866 | — | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL2165867 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL2165865 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL2165863 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL2165864 | — | IC50 | = | 81000.0 | nM | 4.09 |
| CHEMBL2165862 | — | IC50 | = | 82000.0 | nM | 4.09 |
| CHEMBL1392167 | — | IC50 | = | 97000.0 | nM | 4.01 |