Assay Detail
Binding
CHEMBL2167305
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Binding affinity to Aurora kinase A catalytic domain by competition binding assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of highly potent and selective pan-Aurora kinase inhibitors with enhanced in vivo antitumor therapeutic index.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 28 | 8.07 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2163388 | — | — | 1 | 8.60 |
| CHEMBL2163400 | — | — | 1 | 8.55 |
| CHEMBL2163391 | — | — | 1 | 8.40 |
| CHEMBL2163390 | — | — | 1 | 8.40 |
| CHEMBL2163401 | — | — | 1 | 8.40 |
| CHEMBL2163395 | — | — | 1 | 8.38 |
| CHEMBL2163407 | — | — | 1 | 8.35 |
| CHEMBL2163411 | — | — | 1 | 8.29 |
| CHEMBL2163387 | — | — | 1 | 8.25 |
| CHEMBL2163404 | — | — | 1 | 8.24 |
| CHEMBL2163392 | — | — | 1 | 8.20 |
| CHEMBL2163403 | — | — | 1 | 8.20 |
| CHEMBL2163389 | — | — | 1 | 8.19 |
| CHEMBL2163398 | — | — | 1 | 8.06 |
| CHEMBL2163394 | — | — | 1 | 8.03 |
| CHEMBL2163402 | — | — | 1 | 8.00 |
| CHEMBL2163406 | — | — | 1 | 7.98 |
| CHEMBL2163409 | — | — | 1 | 7.96 |
| CHEMBL2163408 | — | — | 1 | 7.94 |
| CHEMBL2163396 | — | — | 1 | 7.91 |
| CHEMBL2163410 | — | — | 1 | 7.90 |
| CHEMBL2163413 | — | — | 1 | 7.88 |
| CHEMBL1822658 | — | — | 1 | 7.82 |
| CHEMBL2163397 | — | — | 1 | 7.77 |
| CHEMBL2163393 | — | — | 1 | 7.71 |
| CHEMBL2163412 | — | — | 1 | 7.60 |
| CHEMBL2163399 | — | — | 1 | 7.60 |
| CHEMBL2163405 | — | — | 1 | 7.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2163388 | — | Kd | = | 2.5 | nM | 8.60 |
| CHEMBL2163400 | — | Kd | = | 2.8 | nM | 8.55 |
| CHEMBL2163391 | — | Kd | = | 4.0 | nM | 8.40 |
| CHEMBL2163390 | — | Kd | = | 4.0 | nM | 8.40 |
| CHEMBL2163401 | — | Kd | = | 4.0 | nM | 8.40 |
| CHEMBL2163395 | — | Kd | = | 4.2 | nM | 8.38 |
| CHEMBL2163407 | — | Kd | = | 4.5 | nM | 8.35 |
| CHEMBL2163411 | — | Kd | = | 5.1 | nM | 8.29 |
| CHEMBL2163387 | — | Kd | = | 5.6 | nM | 8.25 |
| CHEMBL2163404 | — | Kd | = | 5.8 | nM | 8.24 |
| CHEMBL2163392 | — | Kd | = | 6.3 | nM | 8.20 |
| CHEMBL2163403 | — | Kd | = | 6.3 | nM | 8.20 |
| CHEMBL2163389 | — | Kd | = | 6.4 | nM | 8.19 |
| CHEMBL2163398 | — | Kd | = | 8.8 | nM | 8.06 |
| CHEMBL2163394 | — | Kd | = | 9.3 | nM | 8.03 |
| CHEMBL2163402 | — | Kd | = | 10.1 | nM | 8.00 |
| CHEMBL2163406 | — | Kd | = | 10.5 | nM | 7.98 |
| CHEMBL2163409 | — | Kd | = | 11.0 | nM | 7.96 |
| CHEMBL2163408 | — | Kd | = | 11.5 | nM | 7.94 |
| CHEMBL2163396 | — | Kd | = | 12.3 | nM | 7.91 |
| CHEMBL2163410 | — | Kd | = | 12.5 | nM | 7.90 |
| CHEMBL2163413 | — | Kd | = | 13.1 | nM | 7.88 |
| CHEMBL1822658 | — | Kd | = | 15.0 | nM | 7.82 |
| CHEMBL2163397 | — | Kd | = | 16.9 | nM | 7.77 |
| CHEMBL2163393 | — | Kd | = | 19.5 | nM | 7.71 |
| CHEMBL2163412 | — | Kd | = | 25.0 | nM | 7.60 |
| CHEMBL2163399 | — | Kd | = | 25.2 | nM | 7.60 |
| CHEMBL2163405 | — | Kd | = | 39.0 | nM | 7.41 |