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Assay Detail

CHEMBL2167526

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of recombinant Plasmodium falciparum recombinant IspC using [3,4,5-13C3]1-Deoxy-D-xylulose 5-phosphate substrate by photometric assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Plasmodium falciparum
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

α-Substituted β-oxa isosteres of fosmidomycin: synthesis and biological evaluation.
Brücher K, Illarionov B, Held J, Tschan S, Kunfermann A, Pein MK, Bacher A, Gräwert T, Maes L, Mordmüller B, Fischer M, Kurz T.
J Med Chem (2012) 55 : 6566 -6575
PubMed 22731758 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 7.15 8.51

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2164255 1 8.51
CHEMBL2164262 1 7.92
CHEMBL2164256 1 7.85
CHEMBL2164263 1 7.85
CHEMBL2164264 1 7.60
CHEMBL2164260 1 7.57
CHEMBL2164258 1 7.43
CHEMBL2164259 1 7.41
CHEMBL2164261 1 7.19
CHEMBL2164257 FOSMIDOMYCIN SODIUM 1 6.80
CHEMBL2164265 1 6.68
CHEMBL2164266 1 5.82
CHEMBL2164267 1 5.77
CHEMBL2164251 1 5.75
CHEMBL2164252 1 -
CHEMBL2164253 1 -
CHEMBL2164254 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2164255 IC50 = 3.1 nM 8.51
CHEMBL2164262 IC50 = 12.0 nM 7.92
CHEMBL2164256 IC50 = 14.0 nM 7.85
CHEMBL2164263 IC50 = 14.0 nM 7.85
CHEMBL2164264 IC50 = 25.0 nM 7.60
CHEMBL2164260 IC50 = 27.0 nM 7.57
CHEMBL2164258 IC50 = 37.0 nM 7.43
CHEMBL2164259 IC50 = 39.0 nM 7.41
CHEMBL2164261 IC50 = 65.0 nM 7.19
CHEMBL2164257 FOSMIDOMYCIN SODIUM IC50 = 160.0 nM 6.80
CHEMBL2164265 IC50 = 210.0 nM 6.68
CHEMBL2164266 IC50 = 1500.0 nM 5.82
CHEMBL2164267 IC50 = 1700.0 nM 5.77
CHEMBL2164251 IC50 = 1800.0 nM 5.75
CHEMBL2164252 IC50 - -
CHEMBL2164253 IC50 - -
CHEMBL2164254 IC50 - -