Assay Detail
Binding
CHEMBL2167759
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Binding affinity to purified human antithrombin at 64 uM in presence of 37 uM d-myo-inositol 3,4,5,6-tetrakisphosphate by isothermal titration calorimetry
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
In silico discovery of a compound with nanomolar affinity to antithrombin causing partial activation and increased heparin affinity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 1 | 7.73 | 7.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1200644 | FONDAPARINUX SODIUM | 4.0 | 1 | 7.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1200644 | FONDAPARINUX SODIUM | Kd | = | 18.8 | nM | 7.73 |