Assay Detail
Binding
CHEMBL2167993
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ADAMTS-4 using WAAG-3R as substrate preincubated for 15 mins measured after 1 hr
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
A disintegrin and metalloproteinase with thrombospondin motifs 4 (CHEMBL2318) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of highly potent and selective small molecule ADAMTS-5 inhibitors that inhibit human cartilage degradation via encoded library technology (ELT).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.03 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL187092 | — | — | 1 | 8.52 |
| CHEMBL2164113 | — | — | 1 | 5.92 |
| CHEMBL2164094 | — | — | 1 | 5.89 |
| CHEMBL2164121 | — | — | 1 | 5.82 |
| CHEMBL2164120 | — | — | 1 | 5.73 |
| CHEMBL2164122 | — | — | 1 | 5.22 |
| CHEMBL2164111 | — | — | 1 | 5.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL187092 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2164113 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL2164094 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL2164121 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2164120 | — | IC50 | = | 1870.0 | nM | 5.73 |
| CHEMBL2164122 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL2164111 | — | IC50 | = | 8300.0 | nM | 5.08 |