Assay Detail
Binding
CHEMBL2167994
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Inhibition of MMP-13 using 5-FAM-TPGPLGL[Dap- (DNP)]ARRK(5-TAMRA)-amide as substrate after 45 mins
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of highly potent and selective small molecule ADAMTS-5 inhibitors that inhibit human cartilage degradation via encoded library technology (ELT).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.96 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL187092 | — | — | 1 | 9.05 |
| CHEMBL2164113 | — | — | 1 | 5.10 |
| CHEMBL2164111 | — | — | 1 | 5.10 |
| CHEMBL2164094 | — | — | 1 | 4.60 |
| CHEMBL2164122 | — | — | 1 | - |
| CHEMBL2164121 | — | — | 1 | - |
| CHEMBL2164120 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL187092 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL2164113 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL2164111 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL2164094 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL2164122 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL2164121 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL2164120 | — | IC50 | > | 50000.0 | nM | - |