Assay Detail
Binding
CHEMBL2168044
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant hERG expressed in CHO cells by automated patch clamp assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Mitigating hERG Inhibition: Design of Orally Bioavailable CCR5 Antagonists as Potent Inhibitors of R5 HIV-1 Replication.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.27 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2164207 | — | — | 1 | 6.52 |
| CHEMBL2164203 | — | — | 1 | 5.80 |
| CHEMBL2164206 | — | — | 1 | 5.26 |
| CHEMBL2164219 | — | — | 1 | 5.08 |
| CHEMBL2164210 | — | — | 1 | 4.97 |
| CHEMBL2164220 | — | — | 1 | 4.80 |
| CHEMBL2164208 | — | — | 1 | 4.48 |
| CHEMBL2164212 | — | — | 1 | - |
| CHEMBL2164211 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2164207 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2164203 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL2164206 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL2164219 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL2164210 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL2164220 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL2164208 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL2164212 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2164211 | — | IC50 | > | 40000.0 | nM | - |