Assay Detail
Binding
CHEMBL2168085
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Inhibition of Dengue Virus 2 NS2B-NS3 protease using Benzoyl-Nle-Lys-Arg-Arg-AMC as substrate incubated for 3 mins prior to substrate addition by fluorimetric analysis
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | dengue virus type 2 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Critical effect of peptide cyclization on the potency of peptide inhibitors against Dengue virus NS2B-NS3 protease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 5.17 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2304053 | — | — | 1 | 5.85 |
| CHEMBL2448521 | — | — | 1 | 5.66 |
| CHEMBL2304054 | — | — | 1 | 5.60 |
| CHEMBL2304055 | — | — | 1 | 5.46 |
| CHEMBL2304056 | — | — | 1 | 5.30 |
| CHEMBL503461 | — | — | 1 | 5.05 |
| CHEMBL2304052 | — | — | 1 | 4.95 |
| CHEMBL2304057 | — | — | 1 | 4.92 |
| CHEMBL2448522 | — | — | 1 | 4.90 |
| CHEMBL2165105 | — | — | 1 | 4.82 |
| CHEMBL2165096 | — | — | 1 | 4.38 |
| CHEMBL2367770 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2304053 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL2448521 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL2304054 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL2304055 | — | Ki | = | 3500.0 | nM | 5.46 |
| CHEMBL2304056 | — | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL503461 | — | Ki | = | 9000.0 | nM | 5.05 |
| CHEMBL2304052 | — | Ki | = | 11300.0 | nM | 4.95 |
| CHEMBL2304057 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL2448522 | — | Ki | = | 12500.0 | nM | 4.90 |
| CHEMBL2165105 | — | Ki | = | 15100.0 | nM | 4.82 |
| CHEMBL2165096 | — | Ki | = | 42000.0 | nM | 4.38 |
| CHEMBL2367770 | — | Ki | > | 100000.0 | nM | - |