Assay Detail
Binding
CHEMBL2168213
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Competitive inhibition of recombinant Imiglucerase using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate preincubated for 30 mins before substrate addition at pH 5.2 by Dixon plot assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Potent aminocyclitol glucocerebrosidase inhibitors are subnanomolar pharmacological chaperones for treating gaucher disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.19 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2164231 | — | — | 1 | 8.40 |
| CHEMBL2164227 | — | — | 1 | 7.10 |
| CHEMBL2164230 | — | — | 1 | 6.89 |
| CHEMBL2164232 | — | — | 1 | 6.35 |
| CHEMBL408500 | — | — | 1 | 6.18 |
| CHEMBL2164229 | — | — | 1 | 6.17 |
| CHEMBL2164233 | — | — | 1 | 5.76 |
| CHEMBL2163840 | — | — | 1 | 5.41 |
| CHEMBL2164228 | — | — | 1 | 5.36 |
| CHEMBL2163841 | — | — | 1 | 4.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2164231 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2164227 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL2164230 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL2164232 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL408500 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL2164229 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL2164233 | — | IC50 | = | 1720.0 | nM | 5.76 |
| CHEMBL2163840 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL2164228 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL2163841 | — | IC50 | = | 52600.0 | nM | 4.28 |