Assay Detail
Binding
CHEMBL2168216
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to recombinant imiglucerase using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate preincubated for 30 mins before substrate addition by Dixon plot assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Potent aminocyclitol glucocerebrosidase inhibitors are subnanomolar pharmacological chaperones for treating gaucher disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 6.61 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2164231 | — | — | 1 | 9.00 |
| CHEMBL2164227 | — | — | 1 | 7.50 |
| CHEMBL2164230 | — | — | 1 | 7.28 |
| CHEMBL2164232 | — | — | 1 | 6.89 |
| CHEMBL2164229 | — | — | 1 | 6.55 |
| CHEMBL408500 | — | — | 1 | 6.52 |
| CHEMBL2164233 | — | — | 1 | 6.09 |
| CHEMBL2164228 | — | — | 1 | 5.80 |
| CHEMBL2163840 | — | — | 1 | 5.72 |
| CHEMBL2163841 | — | — | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2164231 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL2164227 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL2164230 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL2164232 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL2164229 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL408500 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL2164233 | — | Ki | = | 820.0 | nM | 6.09 |
| CHEMBL2164228 | — | Ki | = | 1580.0 | nM | 5.80 |
| CHEMBL2163840 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL2163841 | — | Ki | = | 17900.0 | nM | 4.75 |