Assay Detail
Functional
CHEMBL2168689
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at rat alpha7 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced response after 2 to 6 days by two electrode voltage clamp assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Oocyte |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL4980) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and nicotinic acetylcholine receptor in vitro and in vivo pharmacological properties of 2'-fluoro-3'-(substituted phenyl)deschloroepibatidine analogues of 2'-fluoro-3'-(4-nitrophenyl)deschloroepibatidine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.62 | 5.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2164663 | — | — | 1 | 5.40 |
| CHEMBL2164664 | — | — | 1 | 4.72 |
| CHEMBL361465 | — | — | 1 | 4.50 |
| CHEMBL2164667 | — | — | 1 | 4.46 |
| CHEMBL372638 | — | — | 1 | 4.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2164663 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL2164664 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL361465 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL2164667 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL372638 | — | IC50 | = | 98000.0 | nM | 4.01 |