Assay Detail
Binding
CHEMBL2168757
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of PXR
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Nuclear receptor subfamily 1 group I member 2 (CHEMBL3401) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of MK-7725, A Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 5.53 | 6.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2164575 | — | — | 1 | 6.17 |
| CHEMBL2164577 | — | — | 1 | 5.96 |
| CHEMBL2164576 | — | — | 1 | 5.75 |
| CHEMBL2164579 | — | — | 1 | 5.72 |
| CHEMBL2164224 | — | — | 1 | 5.62 |
| CHEMBL2164581 | — | — | 1 | 5.46 |
| CHEMBL2164578 | — | — | 1 | 5.18 |
| CHEMBL2164226 | — | — | 1 | 5.00 |
| CHEMBL2164580 | — | — | 1 | 4.93 |
| CHEMBL2023109 | — | — | 1 | - |
| CHEMBL2164225 | — | — | 1 | - |
| CHEMBL2164223 | — | — | 1 | - |
| CHEMBL2164222 | — | — | 1 | - |
| CHEMBL2164582 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2164575 | — | EC50 | = | 677.0 | nM | 6.17 |
| CHEMBL2164577 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL2164576 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL2164579 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL2164224 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL2164581 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL2164578 | — | EC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL2164226 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL2164580 | — | EC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL2023109 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL2164225 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL2164223 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2164222 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL2164582 | — | EC50 | > | 10000.0 | nM | - |