Assay Detail
Binding
CHEMBL2168780
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Inhibition of reductase activity of N-terminal 6His-tagged human AKR1B10 expressed in Escherichia coli BL21(DE3) assessed as pyridine-3-aldehyde reduction
9
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member B10 (CHEMBL5983) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Selective inhibition of the tumor marker aldo-keto reductase family member 1B10 by oleanolic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.63 | 7.05 |
| Ki | 2 | 7.56 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL270067 | ISOLITHOCHOLIC ACID | — | 1 | 7.82 |
| CHEMBL436 | TOLRESTAT | 4.0 | 1 | 7.30 |
| CHEMBL168 | OLEANOLIC_ACID | — | 1 | 7.05 |
| CHEMBL201515 | MASLINIC ACID | — | 1 | 6.20 |
| CHEMBL269277 | BETULINIC ACID | 1.0 | 1 | 5.70 |
| CHEMBL169 | URSOLIC ACID | 2.0 | 1 | 5.40 |
| CHEMBL230006 | ENOXOLONE | 2.0 | 1 | 5.31 |
| CHEMBL404313 | ASIATIC ACID | — | 1 | 5.23 |
| CHEMBL400074 | ERYTHRODIOL | — | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL270067 | ISOLITHOCHOLIC ACID | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL436 | TOLRESTAT | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL168 | OLEANOLIC_ACID | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL201515 | MASLINIC ACID | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL269277 | BETULINIC ACID | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL169 | URSOLIC ACID | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL230006 | ENOXOLONE | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL404313 | ASIATIC ACID | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL400074 | ERYTHRODIOL | IC50 | = | 30000.0 | nM | 4.52 |