Assay Detail
Binding
CHEMBL2168781
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of reductase activity of N-terminal 6His-tagged human recombinant AKR1B1 expressed in Escherichia coli BL21(DE3) assessed as assessed as pyridine-3-aldehyde reduction
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL1900) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Selective inhibition of the tumor marker aldo-keto reductase family member 1B10 by oleanolic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.41 | 4.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269277 | BETULINIC ACID | 1.0 | 1 | 4.96 |
| CHEMBL404313 | ASIATIC ACID | — | 1 | 4.47 |
| CHEMBL169 | URSOLIC ACID | 2.0 | 1 | 4.39 |
| CHEMBL201515 | MASLINIC ACID | — | 1 | 4.14 |
| CHEMBL400074 | ERYTHRODIOL | — | 1 | 4.08 |
| CHEMBL168 | OLEANOLIC_ACID | — | 1 | - |
| CHEMBL230006 | ENOXOLONE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269277 | BETULINIC ACID | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL404313 | ASIATIC ACID | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL169 | URSOLIC ACID | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL201515 | MASLINIC ACID | IC50 | = | 72000.0 | nM | 4.14 |
| CHEMBL400074 | ERYTHRODIOL | IC50 | = | 84000.0 | nM | 4.08 |
| CHEMBL168 | OLEANOLIC_ACID | IC50 | = | 124000.0 | nM | - |
| CHEMBL230006 | ENOXOLONE | IC50 | = | 280000.0 | nM | - |