Assay Detail
Functional
CHEMBL2168975
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Neuroprotective activity in rat PC12 cells expressing SOD1 G93A mutant assessed as increase in cell viability after 48 hrs by CalceinAM-based fluorescence assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | PC-12 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Substituted pyrazolones require N2 hydrogen bond donating ability to protect against cytotoxicity from protein aggregation of mutant superoxide dismutase 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 25 | 6.29 | 7.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1939222 | — | — | 1 | 7.17 |
| CHEMBL2165383 | — | — | 1 | 6.89 |
| CHEMBL2165387 | — | — | 1 | 6.57 |
| CHEMBL2165389 | — | — | 1 | 6.51 |
| CHEMBL2165390 | — | — | 1 | 6.48 |
| CHEMBL2165377 | — | — | 1 | 6.47 |
| CHEMBL2165384 | — | — | 1 | 6.44 |
| CHEMBL2165388 | — | — | 1 | 6.38 |
| CHEMBL2165386 | — | — | 1 | 6.31 |
| CHEMBL2165374 | — | — | 1 | 6.25 |
| CHEMBL2165372 | — | — | 1 | 6.17 |
| CHEMBL2165375 | — | — | 1 | 6.17 |
| CHEMBL2165392 | — | — | 1 | 6.03 |
| CHEMBL2165382 | — | — | 1 | 6.00 |
| CHEMBL2165378 | — | — | 1 | 5.99 |
| CHEMBL2165393 | — | — | 1 | 5.88 |
| CHEMBL2165391 | — | — | 1 | 5.77 |
| CHEMBL2165379 | — | — | 1 | 5.76 |
| CHEMBL2165380 | — | — | 1 | - |
| CHEMBL2165381 | — | — | 1 | - |
| CHEMBL2165376 | — | — | 1 | - |
| CHEMBL2165385 | — | — | 1 | - |
| CHEMBL2165373 | — | — | 1 | - |
| CHEMBL2165371 | — | — | 1 | - |
| CHEMBL2165370 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1939222 | — | EC50 | = | 67.0 | nM | 7.17 |
| CHEMBL2165383 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL2165387 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL2165389 | — | EC50 | = | 310.0 | nM | 6.51 |
| CHEMBL2165390 | — | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL2165377 | — | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL2165384 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL2165388 | — | EC50 | = | 420.0 | nM | 6.38 |
| CHEMBL2165386 | — | EC50 | = | 490.0 | nM | 6.31 |
| CHEMBL2165374 | — | EC50 | = | 560.0 | nM | 6.25 |
| CHEMBL2165372 | — | EC50 | = | 670.0 | nM | 6.17 |
| CHEMBL2165375 | — | EC50 | = | 670.0 | nM | 6.17 |
| CHEMBL2165392 | — | EC50 | = | 930.0 | nM | 6.03 |
| CHEMBL2165382 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2165378 | — | EC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL2165393 | — | EC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL2165391 | — | EC50 | = | 1710.0 | nM | 5.77 |
| CHEMBL2165379 | — | EC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL2165380 | — | EC50 | > | 32000.0 | nM | - |
| CHEMBL2165381 | — | EC50 | > | 32000.0 | nM | - |
| CHEMBL2165376 | — | EC50 | > | 32000.0 | nM | - |
| CHEMBL2165385 | — | EC50 | > | 32000.0 | nM | - |
| CHEMBL2165373 | — | EC50 | > | 32000.0 | nM | - |
| CHEMBL2165371 | — | EC50 | > | 32000.0 | nM | - |
| CHEMBL2165370 | — | EC50 | > | 32000.0 | nM | - |