Assay Detail
Functional
CHEMBL2169251
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human alpha1beta2gamma2L GABAA receptor expressed in Xenopus oocytes assessed as potentiation of GABA-induced current response by two-electrode voltage clamp electrophysiology assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Oocyte |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
GABA-A receptor; agonist GABA site (CHEMBL2109244) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Homo sapiens |
Publication
p-(4-Azipentyl)propofol: a potent photoreactive general anesthetic derivative of propofol.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 5.32 | 5.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2165414 | — | — | 1 | 5.35 |
| CHEMBL526 | PROPOFOL | 4.0 | 1 | 5.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2165414 | — | EC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL526 | PROPOFOL | EC50 | = | 5200.0 | nM | 5.28 |