Assay Detail
Binding
CHEMBL2169664
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant GST-tagged mTOR-mediated 4EBP1 phosphorylation after 90 mins by FRET assay
57
Total Activities
57
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase mTOR (CHEMBL2842) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-based design of a novel series of potent, selective inhibitors of the class I phosphatidylinositol 3-kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 57 | 6.15 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2165051 | — | — | 1 | 8.15 |
| CHEMBL1762782 | — | — | 1 | 8.10 |
| CHEMBL1615182 | — | — | 1 | 7.03 |
| CHEMBL2165052 | — | — | 1 | 6.70 |
| CHEMBL2165039 | — | — | 1 | 6.54 |
| CHEMBL2165270 | — | — | 1 | 6.44 |
| CHEMBL2165037 | — | — | 1 | 6.28 |
| CHEMBL2165038 | — | — | 1 | 6.25 |
| CHEMBL2165016 | — | — | 1 | 5.85 |
| CHEMBL2165031 | — | — | 1 | 5.85 |
| CHEMBL2165026 | — | — | 1 | 5.60 |
| CHEMBL2165004 | — | — | 1 | 5.44 |
| CHEMBL2165015 | — | — | 1 | 5.43 |
| CHEMBL2165017 | — | — | 1 | 5.32 |
| CHEMBL2165041 | — | — | 1 | 5.29 |
| CHEMBL2165268 | — | — | 1 | 5.14 |
| CHEMBL2165269 | — | — | 1 | 5.11 |
| CHEMBL2165044 | — | — | 1 | - |
| CHEMBL2165050 | — | — | 1 | - |
| CHEMBL2165045 | — | — | 1 | - |
| CHEMBL2165046 | — | — | 1 | - |
| CHEMBL2165047 | — | — | 1 | - |
| CHEMBL2165048 | — | — | 1 | - |
| CHEMBL2165049 | — | — | 1 | - |
| CHEMBL2165043 | — | — | 1 | - |
| CHEMBL2165042 | — | — | 1 | - |
| CHEMBL2165040 | — | — | 1 | - |
| CHEMBL2165024 | — | — | 1 | - |
| CHEMBL2165036 | — | — | 1 | - |
| CHEMBL2165035 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2165051 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1762782 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1615182 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL2165052 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2165039 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL2165270 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL2165037 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL2165038 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL2165016 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL2165031 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL2165026 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL2165004 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL2165015 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL2165017 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL2165041 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL2165268 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL2165269 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL2165030 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2165032 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2165033 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2165034 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2165021 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2165009 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2165010 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2165011 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2165012 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2165013 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2165014 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2165018 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2165019 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2165020 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2165003 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2165005 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2165042 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2165044 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2165050 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2165045 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2165046 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2165047 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2165048 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2165049 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2165043 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2165006 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2165040 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2165024 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2165036 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2165035 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2165271 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2165053 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2165008 | — | IC50 | > | 10000.0 | nM | - |