Assay Detail
Binding
CHEMBL2172825
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of glucocerebrosidase N370S mutant in Gaucher patient spleen homogenate using resorufin beta-D-glucopyranoside as substrate incubated for 5 mins prior to substrate addition measured after 20 mins by fluorimetric analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Spleen |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery, structure-activity relationship, and biological evaluation of noninhibitory small molecule chaperones of glucocerebrosidase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 5.50 | 5.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL403714 | — | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL403714 | — | IC50 | = | 3200.0 | nM | 5.50 |