Assay Detail
Binding
CHEMBL2172827
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of wild type glucocerebrosidase in human spleen homogenate using 4-methylumbellifereno-Glc as substrate incubated for 5 mins prior to substrate addition measured after 20 mins by fluorimetric analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Spleen |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery, structure-activity relationship, and biological evaluation of noninhibitory small molecule chaperones of glucocerebrosidase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.85 | 6.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1361379 | — | — | 1 | 6.55 |
| CHEMBL103769 | — | — | 1 | 6.44 |
| CHEMBL403714 | — | — | 1 | 5.66 |
| CHEMBL406121 | — | — | 1 | 5.50 |
| CHEMBL429079 | — | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1361379 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL103769 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL403714 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL406121 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL429079 | — | IC50 | = | 7900.0 | nM | 5.10 |