Assay Detail
Binding
CHEMBL2172830
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Inhibition of wild type glucocerebrosidase using 4-methylumbellifereno-Glc as substrate incubated for 5 mins prior to substrate addition measured after 20 mins by fluorimetric analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery, structure-activity relationship, and biological evaluation of noninhibitory small molecule chaperones of glucocerebrosidase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.61 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2105671 | AFEGOSTAT TARTRATE | 2.0 | 1 | 7.52 |
| CHEMBL403714 | — | — | 1 | 7.52 |
| CHEMBL406121 | — | — | 1 | 7.00 |
| CHEMBL429079 | — | — | 1 | 6.40 |
| CHEMBL103769 | — | — | 1 | 6.15 |
| CHEMBL1361379 | — | — | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2105671 | AFEGOSTAT TARTRATE | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL403714 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL406121 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL429079 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL103769 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL1361379 | — | IC50 | = | 8900.0 | nM | 5.05 |