Assay Detail
Binding
CHEMBL2173038
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GST-tagged recombinant Mcl1 interaction with biotinylated Bim peptide by ELISA based competitive binding assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Induced myeloid leukemia cell differentiation protein Mcl-1 (CHEMBL4361) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and biological activities of polyquinoline derivatives: new Bcl-2 family protein modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 5.52 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL408194 | OBATOCLAX | 3.0 | 1 | 6.30 |
| CHEMBL2171488 | — | — | 1 | 5.68 |
| CHEMBL2171509 | — | — | 1 | 5.64 |
| CHEMBL2171489 | — | — | 1 | 5.46 |
| CHEMBL2171491 | — | — | 1 | 5.10 |
| CHEMBL2171506 | — | — | 1 | 4.94 |
| CHEMBL555017 | GAMBOGIC ACID | — | 1 | - |
| CHEMBL376408 | ABT 737 | 1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL408194 | OBATOCLAX | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL2171488 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL2171509 | — | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL2171489 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL2171491 | — | EC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL2171506 | — | EC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL555017 | GAMBOGIC ACID | EC50 | - | — | - | |
| CHEMBL376408 | ABT 737 | EC50 | - | — | - |