Assay Detail
Binding
CHEMBL2173194
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant 5-lipoxygenase-mediated product formation from arachidonic acid after 5 to 10 mins by HPLC analysis
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL215) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and biological evaluation of a novel class of dual microsomal prostaglandin E2 synthase-1/5-lipoxygenase inhibitors based on 2-[(4,6-diphenethoxypyrimidin-2-yl)thio]hexanoic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 5.36 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL314360 | — | — | 1 | 6.80 |
| CHEMBL1172016 | — | — | 1 | 5.66 |
| CHEMBL1170264 | — | — | 1 | 5.66 |
| CHEMBL1172019 | — | — | 1 | 5.57 |
| CHEMBL1172003 | — | — | 1 | 5.55 |
| CHEMBL1171652 | — | — | 1 | 5.55 |
| CHEMBL1173376 | — | — | 1 | 5.51 |
| CHEMBL1819479 | — | — | 1 | 5.36 |
| CHEMBL461883 | — | — | 1 | 5.33 |
| CHEMBL1171851 | — | — | 1 | 5.31 |
| CHEMBL1819393 | — | — | 1 | 5.31 |
| CHEMBL1172222 | — | — | 1 | 5.30 |
| CHEMBL1171831 | — | — | 1 | 5.18 |
| CHEMBL1172000 | — | — | 1 | 5.17 |
| CHEMBL1172002 | — | — | 1 | 5.17 |
| CHEMBL1173121 | — | — | 1 | 5.16 |
| CHEMBL1819392 | — | — | 1 | 5.14 |
| CHEMBL1171834 | — | — | 1 | 5.05 |
| CHEMBL1173499 | — | — | 1 | 5.05 |
| CHEMBL1172001 | — | — | 1 | 5.03 |
| CHEMBL1171832 | — | — | 1 | 5.03 |
| CHEMBL1819480 | — | — | 1 | 5.00 |
| CHEMBL1819390 | — | — | 1 | - |
| CHEMBL1819391 | — | — | 1 | - |
| CHEMBL1170852 | — | — | 1 | - |
| CHEMBL1819394 | — | — | 1 | - |
| CHEMBL1819395 | — | — | 1 | - |
| CHEMBL1819396 | — | — | 1 | - |
| CHEMBL2170363 | — | — | 1 | - |
| CHEMBL1819397 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL314360 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL1172016 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL1170264 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL1172019 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL1172003 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL1171652 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL1173376 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL1819479 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL461883 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL1171851 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL1819393 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL1172222 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL1171831 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL1172000 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL1172002 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL1173121 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL1819392 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL1171834 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL1173499 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL1172001 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL1171832 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL1819480 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1817687 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL518507 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1171833 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1819478 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1819398 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1819397 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2170363 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1819396 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1819395 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1819394 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1170852 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1819391 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1819390 | — | IC50 | > | 10000.0 | nM | - |