Assay Detail
Binding
CHEMBL2173311
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Aurora A kinase expressed in Escherichia coli using LRRASLG as substrate by coupled enzyme assay
61
Total Activities
61
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Development of o-chlorophenyl substituted pyrimidines as exceptionally potent aurora kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 61 | 7.44 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2170419 | — | — | 1 | 9.10 |
| CHEMBL2170429 | — | — | 1 | 8.70 |
| CHEMBL2170435 | — | — | 1 | 8.68 |
| CHEMBL2170601 | — | — | 1 | 8.60 |
| CHEMBL2169893 | — | — | 1 | 8.54 |
| CHEMBL2170418 | — | — | 1 | 8.52 |
| CHEMBL2170416 | — | — | 1 | 8.51 |
| CHEMBL2170424 | — | — | 1 | 8.50 |
| CHEMBL2170436 | — | — | 1 | 8.48 |
| CHEMBL2170427 | — | — | 1 | 8.43 |
| CHEMBL2170602 | — | — | 1 | 8.41 |
| CHEMBL2170431 | — | — | 1 | 8.40 |
| CHEMBL2170589 | — | — | 1 | 8.35 |
| CHEMBL2170422 | — | — | 1 | 8.29 |
| CHEMBL2170592 | — | — | 1 | 8.21 |
| CHEMBL2170437 | — | — | 1 | 8.18 |
| CHEMBL2170587 | — | — | 1 | 8.07 |
| CHEMBL2170597 | — | — | 1 | 8.00 |
| CHEMBL244793 | — | — | 1 | 7.95 |
| CHEMBL2170413 | — | — | 1 | 7.91 |
| CHEMBL2170414 | — | — | 1 | 7.84 |
| CHEMBL2170417 | — | — | 1 | 7.76 |
| CHEMBL2170404 | — | — | 1 | 7.75 |
| CHEMBL2170421 | — | — | 1 | 7.74 |
| CHEMBL2170441 | — | — | 1 | 7.73 |
| CHEMBL2170420 | — | — | 1 | 7.70 |
| CHEMBL2170415 | — | — | 1 | 7.67 |
| CHEMBL2170411 | — | — | 1 | 7.67 |
| CHEMBL2170412 | — | — | 1 | 7.63 |
| CHEMBL2170409 | — | — | 1 | 7.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2170419 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL2170429 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2170435 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL2170601 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL2169893 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL2170418 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2170416 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL2170424 | — | IC50 | = | 3.17 | nM | 8.50 |
| CHEMBL2170436 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL2170427 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL2170602 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL2170431 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2170589 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL2170422 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL2170592 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL2170437 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL2170587 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL2170597 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL244793 | — | IC50 | = | 11.3 | nM | 7.95 |
| CHEMBL2170413 | — | IC50 | = | 12.3 | nM | 7.91 |
| CHEMBL2170414 | — | IC50 | = | 14.4 | nM | 7.84 |
| CHEMBL2170417 | — | IC50 | = | 17.3 | nM | 7.76 |
| CHEMBL2170404 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL2170421 | — | IC50 | = | 18.3 | nM | 7.74 |
| CHEMBL2170441 | — | IC50 | = | 18.7 | nM | 7.73 |
| CHEMBL2170420 | — | IC50 | = | 19.9 | nM | 7.70 |
| CHEMBL2170411 | — | IC50 | = | 21.4 | nM | 7.67 |
| CHEMBL2170415 | — | IC50 | = | 21.2 | nM | 7.67 |
| CHEMBL2170412 | — | IC50 | = | 23.2 | nM | 7.63 |
| CHEMBL2170409 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL2170430 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL2170591 | — | IC50 | = | 28.1 | nM | 7.55 |
| CHEMBL2170442 | — | IC50 | = | 30.2 | nM | 7.52 |
| CHEMBL2170439 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL2170434 | — | IC50 | = | 35.1 | nM | 7.46 |
| CHEMBL2170596 | — | IC50 | = | 38.2 | nM | 7.42 |
| CHEMBL2170440 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL2170405 | — | IC50 | = | 44.9 | nM | 7.35 |
| CHEMBL2170432 | — | IC50 | = | 46.6 | nM | 7.33 |
| CHEMBL2170588 | — | IC50 | = | 50.2 | nM | 7.30 |
| CHEMBL394816 | — | IC50 | = | 57.6 | nM | 7.24 |
| CHEMBL2170406 | — | IC50 | = | 71.2 | nM | 7.15 |
| CHEMBL244839 | — | IC50 | = | 79.4 | nM | 7.10 |
| CHEMBL2170408 | — | IC50 | = | 116.5 | nM | 6.93 |
| CHEMBL2170586 | — | IC50 | = | 149.0 | nM | 6.83 |
| CHEMBL2170590 | — | IC50 | = | 216.0 | nM | 6.67 |
| CHEMBL2170410 | — | IC50 | = | 253.0 | nM | 6.60 |
| CHEMBL2170598 | — | IC50 | = | 256.0 | nM | 6.59 |
| CHEMBL2170438 | — | IC50 | = | 284.0 | nM | 6.55 |
| CHEMBL2170599 | — | IC50 | = | 281.0 | nM | 6.55 |