Assay Detail
Binding
CHEMBL2173442
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of B-Raf V600E mutant in presence of 100 uM ATP
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase B-raf (CHEMBL5145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Conformation-specific effects of Raf kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.70 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1230020 | PLX-4720 | — | 1 | 7.89 |
| CHEMBL1229517 | VEMURAFENIB | 4.0 | 1 | 7.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1230020 | PLX-4720 | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1229517 | VEMURAFENIB | IC50 | = | 31.0 | nM | 7.51 |