Assay Detail
Binding
CHEMBL2173449
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of b-Raf in human A375 cells assessed phosphorylation of ERK
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | A-375 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase B-raf (CHEMBL5145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Conformation-specific effects of Raf kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.53 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1197798 | — | — | 1 | 8.70 |
| CHEMBL1230020 | PLX-4720 | — | 1 | 7.34 |
| CHEMBL477989 | SB590885 | — | 1 | 6.54 |
| CHEMBL525191 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1197798 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1230020 | PLX-4720 | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL477989 | SB590885 | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL525191 | — | IC50 | < | 1000.0 | nM | - |