Assay Detail
Binding
CHEMBL2173453
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of C-Raf
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
RAF proto-oncogene serine/threonine-protein kinase (CHEMBL1906) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Conformation-specific effects of Raf kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 9.01 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1197798 | — | — | 1 | 9.52 |
| CHEMBL525191 | — | — | 1 | 9.27 |
| CHEMBL477989 | SB590885 | — | 1 | 8.76 |
| CHEMBL1230020 | PLX-4720 | — | 1 | 8.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1197798 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL525191 | — | Ki | = | 0.54 | nM | 9.27 |
| CHEMBL477989 | SB590885 | Ki | = | 1.72 | nM | 8.76 |
| CHEMBL1230020 | PLX-4720 | Ki | = | 3.3 | nM | 8.48 |