Assay Detail
Functional
CHEMBL2173538
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Antagonist activity at human recombinant CXCR4 expressed in CHO cells assessed as inhibition of SDF1a-induced electrical impedance by dielectric spectroscopic analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Noncyclam tetraamines inhibit CXC chemokine receptor type 4 and target glioma-initiating cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.28 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2311028 | PLERIXAFOR OCTAHYDROCHLORIDE | — | 1 | 6.58 |
| CHEMBL2170444 | — | — | 1 | 6.46 |
| CHEMBL2170299 | — | — | 1 | 6.10 |
| CHEMBL2170443 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2311028 | PLERIXAFOR OCTAHYDROCHLORIDE | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL2170444 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL2170299 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL2170443 | — | IC50 | = | 1100.0 | nM | 5.96 |